Recombinant Thrombomodulin anticorps (AA 69-194)

N° du produit ABIN6938551

Cet anticorps anti-Thrombomodulin Monoclonal Souris (Clone rTHBD-1591) (ABIN6938551) détecte spécifiquement Thrombomodulin dans IHC et ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant Thrombomodulin anticorps (AA 69-194) (ABIN6938551)

Antigène: Thrombomodulin (THBD)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Thrombomodulin est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Clone: RTHBD-1591

Détail du produit anti-Thrombomodulin anticorps

Épitope: AA 69-194

Fonction: Recombinant Thrombomodulin / CD141 (Endothelial Cell Marker) Antibody

Specificité: It recognizes a protein of 75kDa, identified as Thrombomodulin. Thrombomodulin is a transmembrane glycoprotein with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytio-trophoblasts of placenta also express thrombomodulin. This protein is present in almost all of benign vascular tumors and majority of malignant vascular tumors (Kaposi's sarcoma, angiosarcoma, and epithelioid hemangioendothelioma). Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. Recently, thrombomodulin antibody has been used for mesothelial cells and malignant mesotheliomas.

Réactivité croisée (Details): Human.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogène: Recombinant fragment (around aa 69-194) of human Thrombomodulin (CD141) protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application:

Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10 mM Tris buffer with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Positive_Control: THP1 cells. Placenta, Angiosarcoma, Bladder or Cervical Carcinoma.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Thrombomodulin

Antigène: Thrombomodulin (THBD)

Autre désignation: THBD

Sujet:

AHUS6, BDCA3, CD141, Fetomodulin, Thbd, THPH12, THRM, Thrombomodulin (TM)

Angiosarcoma, Bladder or Cervical Carcinoma., THP1 cells. Placenta

Poids moléculaire: 100kDa

ID gène: 7056, 2030

UniProt: P07204