Recombinant TIMP1 anticorps
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- Antigène Voir toutes TIMP1 Anticorps
- TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))
- Type d'anticorp
- Recombinant Antibody
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp TIMP1 est non-conjugé
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Application
- ELISA, Coating (Coat)
- Specificité
- TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases -1, -2, -3 and -4) complex with metalloproteinases such as collagenases, gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 is identical to EPA (erythroid-potentiation activity). PTH has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart tissues. Studies have demonstrated that TIMP1 is useful as a biomarker for early detection of colorectal cancer, outperforming CEA. Additionally, TIMP1 studies have demonstrated its role in CRC tumorigenesis, as well as observing its overexpression in metastatic lymph nodes.
- Réactivité croisée (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Recombinant human full-length TIMP1 protein
- Clone
- TIMP1-1944R
- Isotype
- IgG
- Top Product
- Discover our top product TIMP1 Anticorps primaire
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- Indications d'application
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Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Optimal dilution for a specific application should be determined.
Positive_Control: 293 cell extract or rat brain lysate. Human colon carcinoma.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))
- Autre désignation
- TIMP1 (TIMP1 Produits)
- Synonymes
- anticorps TIMP-1, anticorps TIMP1, anticorps DKFZp468A0912, anticorps CLGI, anticorps EPA, anticorps EPO, anticorps HCI, anticorps TIMP, anticorps Timp, anticorps Clgi, anticorps TIMP metallopeptidase inhibitor 1, anticorps tissue inhibitor of metalloproteinase 1, anticorps TIMP1, anticorps Timp1
- Sujet
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Clgi, Collagenase inhibitor, Collagenase inhibitor, Human, EPA, EPO, Erythroid Potentiating Activity, Erythroid-potentiating activity, Fibroblast collagenase inhibitor, FLJ90373, HCI, Human Collagenase Inhibitor, Metalloproteinase inhibitor 1, Metalloproteinase inhibitor 1 precursor, TIMP 1, TIMP, TIMP metallopeptidase inhibitor 1, TIMP-1, TIMP1 protein, Tissue Inhibitor of Metalloproteinase 1, Tissue inhibitor of metalloproteinases 1,TIMP1 (Colorectal and Lymph Node Metastasis Marker)
Cellular localisation: Secreted. Cytoplasm. - Poids moléculaire
- 23kDa
- ID gène
- 7076, 522632
- UniProt
- P01033
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