Tyrosinase-Related Protein 1 anticorps (AA 257-377)

N° du produit ABIN6938703

L’anticorps anti-Tyrosinase-Related Protein 1 Monoclonal Souris est utilisé pour la détection de Tyrosinase-Related Protein 1 dans des échantillons de Humain. Il a été validé pour IHC et ELISA.

Aperçu rapide pour Tyrosinase-Related Protein 1 anticorps (AA 257-377) (ABIN6938703)

Antigène: Tyrosinase-Related Protein 1 (TYRP1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Tyrosinase-Related Protein 1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Clone: TYRP1-3280

Détail du produit anti-Tyrosinase-Related Protein 1 anticorps

Épitope: AA 257-377

Fonction: Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Antibody

Specificité: It reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

Réactivité croisée (Details): Human.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogène: A recombinant fragment (around aa 257-377) of human TYRP1 protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Information d'application

Indications d'application:

Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: SK-MEL-23, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells. Human skin or melanoma tissues (IHC).

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Tyrosinase-Related Protein 1

Antigène: Tyrosinase-Related Protein 1 (TYRP1)

Autre désignation: TYRP1

Sujet:

5, 6 dihydroxyindole 2 carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, Associated with iris pigmentation, CAS2, Catalase B (CATB), DHICA oxidase, Glycoprotein75 (GP75), Melanoma antigen gp75

SK-MEL-19, SK-MEL-23, SK-MEL-30, SK-MEL-37 cells. Human skin or melanoma tissues (IHC).

Poids moléculaire: 75kDa

ID gène: 7306, 270279

UniProt: P17643