Peroxiredoxin 4 anticorps

N° du produit ABIN6939084

Cet anticorps anti-Peroxiredoxin 4 est un anticorps Souris Monoclonal détectant Peroxiredoxin 4 dans ELISA et Coat. Adapté pour Humain.

Aperçu rapide pour Peroxiredoxin 4 anticorps (ABIN6939084)

Antigène: Peroxiredoxin 4 (PRDX4)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Peroxiredoxin 4 est non-conjugé

Application: ELISA, Coating (Coat)

Clone: CPTC-PRDX4-2

Détail du produit anti-Peroxiredoxin 4 anticorps

Specificité: The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX IV gene is expressed in many tissues. It exists as a precursor protein, which is only detected in testis, and aprocessed secreted form. PRX IV is highly expressed in lung cancer and is necessary for the promotion of lung cancer in vitro. Studies have demonstrated that PRX IV positive expression is significantly correlated with recurrences and shorter disease-free survival in patients with early-stage lung squamous cell carcinoma, and therefore can be used as a prognostic marker in lung squamous cell carcinoma.

Réactivité croisée (Details): Human,

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length human PRDX4 protein

Isotype: IgG2b

Information d'application

Indications d'application:

Positive Control: HepG2, HeLa and Jurkat cell lysates. Ovarian carcinoma tissue.

Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.

Date de péremption: 24 months

Détails sur Peroxiredoxin 4

Antigène: Peroxiredoxin 4 (PRDX4)

Autre désignation: PRDX4

Sujet: Antioxidant enzyme AOE372, EC 1.11.1.15, Thioredoxin dependent peroxide reductase A0372, TRANK,Peroxiredoxin 4 (Prognostic Marker for Lung SqCC)
Cellular localisation: Cytoplasm. Secreted.

Poids moléculaire: 27kDa

ID gène: 10549, 83383

UniProt: Q13162