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FAF1 anticorps

FAF1 Reactivité: Humain WB, IHC (f) Hôte: Souris Monoclonal CPTC-FAF1-2 unconjugated
N° du produit ABIN6939120
  • Antigène Voir toutes FAF1 Anticorps
    FAF1 (Fas (TNFRSF6) Associated Factor 1 (FAF1))
    Reactivité
    • 54
    • 30
    • 29
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 42
    • 12
    Souris
    Clonalité
    • 44
    • 10
    Monoclonal
    Conjugué
    • 33
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FAF1 est non-conjugé
    Application
    • 47
    • 16
    • 14
    • 13
    • 13
    • 7
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificité
    In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved 'death domain' and belonging to the TNF receptor superfamily. TRADD, FADD and RIP are FAS/TNF-RI interacting proteins that contain a death domain homologous region (DDH). TRADD (TNF-RI-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-RI via their DDH regions, while RIP associates exclusively with FAS. An additional FAS interacting protein designated FAF1, for FAS-associated protein factor-1, binds with the cytoplasmic tail of wildtype but not LPR mutant FAS. When overexpressed in cells, FAF1 enhances the efficiency of FAS-mediated apoptosis. In contrast to TRADD, FADD and RIP, FAF1 lacks a DDH and cannot induce apoptosis independently of FAS activation.
    Réactivité croisée (Details)
    Human,
    Purification
    200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.
    Immunogène
    Recombinant human full-length FAF1 protein
    Clone
    CPTC-FAF1-2
    Isotype
    IgG2b
  • Indications d'application

    Positive Control: HEK293, MCF-7, HeLa whole cell lysate. Human testis, prostate, breast carcinoma or colon carcinoma.

    Known Application: Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
    Date de péremption
    24 months
  • Antigène
    FAF1 (Fas (TNFRSF6) Associated Factor 1 (FAF1))
    Autre désignation
    FAF1 (FAF1 Produits)
    Synonymes
    anticorps faf1, anticorps MGC53741, anticorps MGC80303, anticorps FAF1, anticorps zgc:55752, anticorps wu:fc25h12, anticorps HFAF1s, anticorps UBXD12, anticorps UBXN3A, anticorps hFAF1, anticorps AA408698, anticorps Dffrx, anticorps Fam, anticorps Fas (TNFRSF6) associated factor 1 S homeolog, anticorps Fas (TNFRSF6) associated factor 1 L homeolog, anticorps Fas associated factor 1, anticorps Fas (TNFRSF6) associated factor 1, anticorps Fas-associated factor 1, anticorps faf1.S, anticorps faf1.L, anticorps FAF1, anticorps faf1, anticorps Faf1
    Sujet
    CGI-03, FAS-associated factor 1, HFAF1s, UBX domain-containing protein 12, UBX domain-containing protein 3A,Fas (TNFRSF6) associated factor 1
    Cellular localisation: Nucleus.
    Poids moléculaire
    75-80kDa
    ID gène
    11124, 530402
    UniProt
    Q9UNN5
    Pathways
    Maintenance of Protein Location
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