Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

CPS1 anticorps

CPS1 Reactivité: Humain, Chien IHC, StM Hôte: Souris Monoclonal CPS1-1022 unconjugated
N° du produit ABIN6939175
  • Antigène Voir toutes CPS1 Anticorps
    CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))
    Reactivité
    • 54
    • 29
    • 14
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain, Chien
    Hôte
    • 63
    • 6
    Souris
    Clonalité
    • 52
    • 17
    Monoclonal
    Conjugué
    • 28
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CPS1 est non-conjugé
    Application
    • 31
    • 24
    • 14
    • 14
    • 12
    • 10
    • 9
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Specificité
    This MAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC's occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
    Purification
    Purified by Protein A/G
    Immunogène
    Recombinant human CPS1 protein
    Clone
    CPS1-1022
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CPS1 Anticorps primaire
  • Indications d'application

    Positive Control: HeLa cells. Liver or Hepatocellular Carcinoma (HCC).

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))
    Autre désignation
    CPS1 (CPS1 Produits)
    Synonymes
    anticorps CPSASE1, anticorps cps, anticorps 4732433M03Rik, anticorps CPS, anticorps D1Ucla3, anticorps Cps1, anticorps carbamoyl-phosphate synthase 1, anticorps carbamoyl-phosphate synthase 1 L homeolog, anticorps carbamoyl-phosphate synthetase 1, anticorps peptidase M20 domain containing 1, anticorps CPS1, anticorps Cps1, anticorps cps1.L, anticorps cps1, anticorps PM20D1
    Poids moléculaire
    ~165kDa
    ID gène
    1373
    UniProt
    P31327
    Pathways
    Response to Growth Hormone Stimulus, Cellular Glucan Metabolic Process
Vous êtes ici:
Support technique