Cathepsin K anticorps (AA 163-274)

N° du produit ABIN6939219

L’anticorps Souris Monoclonal anti-Cathepsin K a été validé pour IHC et StM. Il convient pour détecter Cathepsin K dans des échantillons de Humain.

Aperçu rapide pour Cathepsin K anticorps (AA 163-274) (ABIN6939219)

Antigène: Cathepsin K (CTSK)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Cathepsin K est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Clone: CTSK-2791

Détail du produit anti-Cathepsin K anticorps

Épitope: AA 163-274

Purification: Purified by Protein A/G

Immunogène: Recombinant fragment of human Cathepsin K protein (around aa 163-274) (exact sequence is proprietary)

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: Human liver or breast tissue (IHC).

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Cathepsin K

Antigène: Cathepsin K (CTSK)

Autre désignation: CTSK

Sujet: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

Poids moléculaire: 39kDa

ID gène: 1513

UniProt: P43235

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades