BTLA anticorps

N° du produit ABIN6939222

Cet anticorps Souris Monoclonal détecte spécifiquement BTLA dans ELISA et Coat. Il présente une réactivité envers Humain.

Aperçu rapide pour BTLA anticorps (ABIN6939222)

Antigène: BTLA (B and T Lymphocyte Associated (BTLA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BTLA est non-conjugé

Application: ELISA, Coating (Coat)

Clone: BTLA-1528

Détail du produit anti-BTLA anticorps

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length human BTLA protein

Isotype: IgG2b kappa

Information d'application

Indications d'application:

Positive Control: Human lymph node or MDAMB468 xenograft.

Known Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur BTLA

Antigène: BTLA (B and T Lymphocyte Associated (BTLA))

Autre désignation: BTLA

Sujet: B and T lymphocyte attenuator (BTLA) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T-cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are coinhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T-cell activation by propagating inhibitory signals through BTLA. The BTLAHVEM interaction is conserved between Mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation.

Poids moléculaire: 33kDa

ID gène: 151888

Pathways: Cancer Immune Checkpoints