Desmoglein 3 anticorps (AA 379-491)

N° du produit ABIN6939268

Cet anticorps anti-Desmoglein 3 est un anticorps Souris Monoclonal détectant Desmoglein 3 dans IHC et StM. Adapté pour Humain.

Aperçu rapide pour Desmoglein 3 anticorps (AA 379-491) (ABIN6939268)

Antigène: Desmoglein 3 (DSG3)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Desmoglein 3 est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Clone: DSG3-2840

Détail du produit anti-Desmoglein 3 anticorps

Épitope: AA 379-491

Specificité: Recognizes a protein of 130 kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80 % ) and specificity (100 %) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.

Purification: Purified by Protein A/G

Immunogène: Recombinant fragment (around aa 379-491) human DSG3 protein (exact sequence is proprietary)

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: A431 cells. Skin or Lung Squamous Cell Carcinoma (SCC).

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Desmoglein 3

Antigène: Desmoglein 3 (DSG3)

Autre désignation: DSG3

Poids moléculaire: 130kDa

ID gène: 1830

UniProt: P32926