Emerin anticorps (AA 56-167)

N° du produit ABIN6939303

Cet anticorps anti-Emerin Monoclonal Souris (Clone EMD-2167) (ABIN6939303) détecte spécifiquement Emerin dans WB, IHC et IF. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Emerin anticorps (AA 56-167) (ABIN6939303)

Antigène: Emerin (EMD)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Emerin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: EMD-2167

Détail du produit anti-Emerin anticorps

Épitope: AA 56-167

Fonction: Emerin (Papillary Thyroid Carcinoma and EDMD Marker) Antibody

Specificité: Emerin is a member of the nuclear lamina associated protein family. It is ubiquitously expressed and localized to the nuclear membrane in normal cells. Mutations of the gene that encodes emerin result in the X-linked recessive disease Emery-Dreifuss muscular dystrophy (EDMD), which is characterized by slowly progressing contractures, skeletal muscle wasting and cardiomyopathy. Reportedly, lack of Emerin expression is one cause of EDMD. Emerin is involved in the association of the nuclear membrane with the lamina, and is localized specifically to desmosomes and fasciae adherents in the heart. Identification of nuclear membrane irregularities with anti-emerin antibody has been reported useful in diagnosing papillary thyroid carcinoma.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant human Emerin protein fragment (around aa 56-167) (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application:

Positive Control: K-562, HeLa or Jurkat cells. Kidney or Skin.

Known Application: Western Blot (0.5-2 μg/mL), Immunofluorescence (1-3 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Emerin

Antigène: Emerin (EMD)

Autre désignation: EMD

Sujet:

EMD, Emerin, Emery Dreifuss muscular dystrophy (EDMD), STA

HeLa or Jurkat cells. Kidney or Skin., K-562

Poids moléculaire: 37kDa

ID gène: 2010, 522823

UniProt: P50402