ESR2 anticorps

N° du produit ABIN6939353

L’anticorps Souris Monoclonal anti-ESR2 a été validé pour ELISA, IHC et Coat. Il convient pour détecter ESR2 dans des échantillons de Humain.

Aperçu rapide pour ESR2 anticorps (ABIN6939353)

Antigène: ESR2 (Estrogen Receptor 2 (ESR2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ESR2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Coating (Coat)

Clone: ESR2-3207

Détail du produit anti-ESR2 anticorps

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length human ESR2 protein

Isotype: IgG2b kappa

Information d'application

Indications d'application:

Positive Control: Ovarian, breast, bladder, gastric or salivary carcinoma (IHC).

Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur ESR2

Antigène: ESR2 (Estrogen Receptor 2 (ESR2))

Autre désignation: ESR2

Sujet: Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.

Poids moléculaire: 53-59kDa

ID gène: 2100

UniProt: Q92731

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling