CD46 anticorps

N° du produit ABIN6940026

Cet anticorps Souris Monoclonal détecte spécifiquement CD46 dans FACS, IF et Func. Il présente une réactivité envers Humain.

Aperçu rapide pour CD46 anticorps (ABIN6940026)

Antigène: CD46

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD46 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)

Clone: 122-2

Détail du produit anti-CD46 anticorps

Purification: Purified by Protein A/G

Immunogène: Recombinant human CD46 protein

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: HeLa, K-562 or MOLT-4 cells. Kidney.

Known Application: Functional Studies (Order Ab without Azide),Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur CD46

Antigène: CD46

Autre désignation: CD46

Sujet: CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Poids moléculaire: 56-66kDa

ID gène: 4179

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization