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NFE2L1 anticorps

NFE2L1 Reactivité: Humain WB, IHC, StM Hôte: Souris Monoclonal NRF1-2609 unconjugated
N° du produit ABIN6940224
  • Antigène Voir toutes NFE2L1 Anticorps
    NFE2L1 (Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1))
    Reactivité
    • 42
    • 19
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 38
    • 4
    Souris
    Clonalité
    • 39
    • 3
    Monoclonal
    Conjugué
    • 22
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NFE2L1 est non-conjugé
    Application
    • 30
    • 21
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Staining Methods (StM)
    Purification
    Purified by Protein A/G
    Immunogène
    Recombinant full-length human NRF1 protein
    Clone
    NRF1-2609
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product NFE2L1 Anticorps primaire
  • Indications d'application

    Positive Control: Ubiquitous expression, strongest in skeletal muscle.

    Known Application: Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    NFE2L1 (Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1))
    Autre désignation
    NFE2L1 (NFE2L1 Produits)
    Synonymes
    anticorps LCR-F1, anticorps NRF1, anticorps TCF11, anticorps AA408798, anticorps AW212678, anticorps Lcrf1, anticorps TCF-11, anticorps nfe2l1, anticorps nuclear factor, erythroid 2 like 1, anticorps nuclear factor, erythroid derived 2,-like 1, anticorps nuclear factor, erythroid 2-like 1, anticorps nuclear factor, erythroid 2 like 1 S homeolog, anticorps nuclear factor, erythroid 2-like 1a, anticorps NFE2L1, anticorps Nfe2l1, anticorps nfe2l1.S, anticorps nfe2l1a
    Sujet
    The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK, and it regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (MAREs). A family of NF-E2 related proteins, which are collectively known as the Cap 'n' collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind MARE sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, JunB and JunD) to activate gene expression, specifically the detoxifying enzyme, NQO1. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1. Nrf3 is highly expressed in placenta, B cells and monocytes.
    Poids moléculaire
    30kDa (bZIP region), 65-120kDa (glycosylated)
    ID gène
    4899
    UniProt
    Q16656
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