PAX6 anticorps (N-Term)

N° du produit ABIN6940258

Cet anticorps anti-PAX6 Monoclonal Souris (Clone PAX6-1166) (ABIN6940258) détecte spécifiquement PAX6 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PAX6 anticorps (N-Term) (ABIN6940258)

Antigène: PAX6 (Paired Box 6 (PAX6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PAX6 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: PAX6-1166

Détail du produit anti-PAX6 anticorps

Épitope: AA 1-300, N-Term

Fonction: PAX6 (Stem Cell Marker) Antibody

Specificité: Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters' anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (N-terminus, aa 1-300) of human PAX6 protein

Isotype: IgG1, kappa

Information d'application

Indications d'application:

Positive Control: Pancreas, Cerebellum or Stomach.

Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris Buffer with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur PAX6

Antigène: PAX6 (Paired Box 6 (PAX6))

Autre désignation: PAX6

Sujet:

AN2, Aniridia type II protein, Oculorhombin, Paired box gene 6 (aniridia keratitis), Paired box homeotic gene 6, Paired box protein Pax-6, Sey, WAGR

Cerebellum or Stomach., Pancreas

Poids moléculaire: 47kDa

ID gène: 5080, 611376, 33870

UniProt: P26367

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis