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ACP5 anticorps

ACP5 Reactivité: Humain, Souris, Rat IHC, IF, FACS, StM Hôte: Souris Monoclonal SPM601 unconjugated
N° du produit ABIN6940365
  • Antigène Voir toutes ACP5 Anticorps
    ACP5 (Acid Phosphatase 5, Tartrate Resistant (ACP5))
    Reactivité
    • 77
    • 41
    • 27
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 60
    • 22
    • 2
    • 2
    Souris
    Clonalité
    • 63
    • 23
    Monoclonal
    Conjugué
    • 49
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ACP5 est non-conjugé
    Application
    • 64
    • 28
    • 20
    • 19
    • 9
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Staining Methods (StM)
    Specificité
    It recognizes a protein of 35 kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis.Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher's Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.
    Purification
    Purified by Protein A/G
    Immunogène
    Recombinant full-length human ACP5 protein
    Clone
    SPM601
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product ACP5 Anticorps primaire
  • Indications d'application

    Positive Control: HepG2, 293T, K562 or RPMI-8226 cells. Spleen from Hairy Cell Leukemia (HCL) patient.

    Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (0.5-1 μg/mL), Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    ACP5 (Acid Phosphatase 5, Tartrate Resistant (ACP5))
    Autre désignation
    ACP5 (ACP5 Produits)
    Synonymes
    anticorps SPENCDI, anticorps TRAP, anticorps acp5, anticorps sb:cb576, anticorps zgc:63825, anticorps wu:fb19f01, anticorps wu:fb30b03, anticorps wu:fi14e01, anticorps wu:fj66f03, anticorps MGC78938, anticorps MGC89674, anticorps TR-AP, anticorps zgc:92339, anticorps TRACP, anticorps TTRRAP, anticorps Trap, anticorps UF, anticorps acid phosphatase 5, tartrate resistant, anticorps acid phosphatase 5a, tartrate resistant, anticorps acid phosphatase 5, tartrate resistant S homeolog, anticorps tartrate resistant acid phosphatase, anticorps Tartrate-resistant acid phosphatase type 5, anticorps tartrate-resistant acid phosphatase type 5, anticorps acid phosphatase 5b, tartrate resistant, anticorps ACP5, anticorps acp5a, anticorps acp5.S, anticorps acp5, anticorps NAEGRDRAFT_81291, anticorps ppa5, anticorps LOC100282899, anticorps acp5b, anticorps Acp5
    Poids moléculaire
    35kDa
    ID gène
    54
    UniProt
    P13686
    Pathways
    Transition Metal Ion Homeostasis
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