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ZFYVE28 anticorps

ZFYVE28 Reactivité: Humain IHC, StM Hôte: Souris Monoclonal LST2-2426 unconjugated
N° du produit ABIN6940433
  • Antigène Voir toutes ZFYVE28 Anticorps
    ZFYVE28 (Zinc Finger, FYVE Domain Containing 28 (ZFYVE28))
    Reactivité
    • 21
    • 11
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 19
    • 2
    Souris
    Clonalité
    • 20
    • 1
    Monoclonal
    Conjugué
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp ZFYVE28 est non-conjugé
    Application
    • 19
    • 13
    • 13
    • 4
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Purification
    Purified by Protein A/G
    Immunogène
    Recombinant full-length human ZFYVE28 protein
    Clone
    LST2-2426
    Isotype
    IgG2a kappa
  • Indications d'application

    Positive Control: PC3 cells. Testis, Brain, Colon, Kidney or Stomach.

    Known Application: Immunohistochemistry (Formalin-fixed) (0.1-0.2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    ZFYVE28 (Zinc Finger, FYVE Domain Containing 28 (ZFYVE28))
    Autre désignation
    ZFYVE28 (ZFYVE28 Produits)
    Synonymes
    anticorps LST2, anticorps LYST2, anticorps 9630058O20Rik, anticorps Gm146, anticorps mKIAA1643, anticorps id:ibd1374, anticorps zgc:152894, anticorps zinc finger FYVE-type containing 28, anticorps zinc finger, FYVE domain containing 28, anticorps ZFYVE28, anticorps Zfyve28, anticorps zfyve28
    Sujet
    ZFYVE28 belongs to the lst-2 family. It contains 1 FYVE-type zinc finger. The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not mono-ubiquitinated at Lys-87. Mono-ubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. ZFYVE28 is a negative regulator of epidermal growth factor receptor (EGFR) signaling. It acts by promoting EGFR degradation in endosomes when not mono-ubiquitinated. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs.
    Poids moléculaire
    96kDa
    ID gène
    57732
    Pathways
    EGFR Signaling Pathway
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