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SOX4 anticorps

SOX4 Reactivité: Humain IHC, StM Hôte: Souris Monoclonal SOX4-2540 unconjugated
N° du produit ABIN6940617
  • Antigène Voir toutes SOX4 Anticorps
    SOX4 (SRY (Sex Determining Region Y)-Box 4 (SOX4))
    Reactivité
    • 38
    • 20
    • 17
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 32
    • 6
    Souris
    Clonalité
    • 33
    • 5
    Monoclonal
    Conjugué
    • 20
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SOX4 est non-conjugé
    Application
    • 32
    • 17
    • 13
    • 13
    • 9
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Purification
    Purified by Protein A/G
    Immunogène
    Recombinant full-length human SOX4 protein
    Clone
    SOX4-2540
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product SOX4 Anticorps primaire
  • Indications d'application

    Positive Control: Breast or Colon Carcinoma.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    SOX4 (SRY (Sex Determining Region Y)-Box 4 (SOX4))
    Autre désignation
    SOX4 (SOX4 Produits)
    Synonymes
    anticorps EVI16, anticorps AA682046, anticorps Sox-4, anticorps sox4, anticorps wu:fb82f08, anticorps wu:fq41g10, anticorps zgc:65850, anticorps zgc:77392, anticorps SRY-box 4, anticorps SRY box 4, anticorps SRY (sex determining region Y)-box 4, anticorps SRY (sex determining region Y)-box 4a, anticorps SOX4, anticorps Sox4, anticorps sox4a
    Sujet
    SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors with a critical role in embryonic development and in cell-fate determination during organogenesis of the heart, pancreas, brain, and in B and T lymphocyte differentiation. SOX4 gene expression is upregulated in many cancer types, and increased SOX4 activity contributes to cellular transformation, cell survival, and metastasis. Gene expression profiling has uncovered SOX4 with upregulated activity during TGF--induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells. SOX4 is indispensable for EMT and cell survival invitro and for primary tumor growth and metastasis invivo. SOX4 is identified as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2.
    Poids moléculaire
    47kDa
    ID gène
    6659
    UniProt
    Q06945
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