STAR anticorps (AA 39-108)

N° du produit ABIN6940667

Cet anticorps anti-STAR Monoclonal Souris (Clone STAR-2154) (ABIN6940667) détecte spécifiquement STAR dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour STAR anticorps (AA 39-108) (ABIN6940667)

Antigène: STAR (Steroidogenic Acute Regulatory Protein (STAR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp STAR est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: STAR-2154

Détail du produit anti-STAR anticorps

Épitope: AA 39-108

Fonction: StAR (Steroidogenic Acute Regulator) (Leydig Cell Marker) Antibody

Specificité: Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone.It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa 39-108) of human STAR protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application:

Positive Control: K-562 cells. Adrenal or Testicular Carcinoma.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur STAR

Antigène: STAR (Steroidogenic Acute Regulatory Protein (STAR))

Autre désignation: STAR

Sujet:

Cholesterol trafficker, Luteinizing hormone induced protein, Mitochondrial steroid acute regulatory protein, StAR, StAR related lipid transfer (START) domain containing 1, StARD1, START domain-containing protein 1, Steroid acute regulatory protein, Steroidogenic acute regulator (STAR), Steroidogenic acute regulatory protein mitochondrial

K-562 cells. Human adrenal or testicular carcinoma.

Poids moléculaire: 30kDa

ID gène: 6770, 521535

UniProt: P49675

Pathways: Metabolism of Steroid Hormones and Vitamin D, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis