Transgelin anticorps

N° du produit ABIN6940678

Détail du produit anti-Transgelin anticorps

Antigène: Transgelin (TAGLN)

Reactivité: Humain, Souris, Boeuf (Vache), Lapin, Porc

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Transgelin est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Specificité: This MAb recognizes a 22 kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length human transgelin (TAGLN) protein.

Clone: TAGLN-247

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: U-2 OS, Hs68 or WI 38 cells. Colon carcinoma.

Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Transgelin

Antigène: Transgelin (TAGLN)

Autre désignation: TAGLN (TAGLN Produits)

Synonymes: anticorps MGC68550, anticorps sm22, anticorps smcc, anticorps tagln1, anticorps ws3-10, anticorps MGC107855, anticorps SM22, anticorps SMCC, anticorps TAGLN1, anticorps WS3-10, anticorps Sm22, anticorps Sm22a, anticorps Ws310, anticorps SM22A, anticorps zgc:153186, anticorps transgelin L homeolog, anticorps transgelin, anticorps tagln.L, anticorps tagln, anticorps LOC732906, anticorps TAGLN, anticorps tagl, anticorps LOC100009332, anticorps Tagln

Poids moléculaire: 22kDa

ID gène: 6876

UniProt: Q01995