TPSAB1 anticorps (AA 115-233)

N° du produit ABIN6940799

Cet anticorps anti-TPSAB1 Monoclonal Souris (Clone TPSAB1-1961) (ABIN6940799) détecte spécifiquement TPSAB1 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour TPSAB1 anticorps (AA 115-233) (ABIN6940799)

Antigène: TPSAB1 (Tryptase alpha/beta 1 (TPSAB1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TPSAB1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: TPSAB1-1961

Détail du produit anti-TPSAB1 anticorps

Épitope: AA 115-233

Fonction: Tryptase (Mast Cell Marker) Antibody

Specificité: Tryptases comprise a family of trypsin-like serine proteases (peptidase family S1). Tryptases are stored in mast cell secretory granules and basophils. Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Tryptases are released into the extracellular environment and are resistant to all known endogenous proteinase inhibitors. This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation. Mastocytosis is a term collectively used for a group of disorders in which there is abnormal accumulation of mast cells in one or multiple organs. Anti-tryptase, combined with anti-CD2, anti-CD25, and anti-CD117, can be useful in identifying reactive mast cell hyperplasia, myelogenous neoplasms, mast cell leukemia, and mastocytosis.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant human Tryptase protein fragment (around aa 115-233) (Exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application:

Positive Control: Skin or Tonsil.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur TPSAB1

Antigène: TPSAB1 (Tryptase alpha/beta 1 (TPSAB1))

Autre désignation: TPSAB1

Sujet:

Lung Tryptase, Mast cell alpha II Tryptase, Mast cell beta I Tryptase, Mast cell protease 7, Mast cell protease II, MCP7, Pituitary Tryptase, Skin Tryptase, TPS1, TPSAB1, TPSB1, Tryptase 1, Tryptase alpha 1, Tryptase skin

Skin or Tonsil.

Poids moléculaire: 31-36kDa

ID gène: 7177, 405479

UniProt: Q15661