Tyrosinase-Related Protein 1 anticorps (AA 257-377)

N° du produit ABIN6940830

Cet anticorps anti-Tyrosinase-Related Protein 1 est un anticorps Souris Monoclonal détectant Tyrosinase-Related Protein 1 dans IHC, ELISA, StM et Coat. Adapté pour Humain.

Aperçu rapide pour Tyrosinase-Related Protein 1 anticorps (AA 257-377) (ABIN6940830)

Antigène: Tyrosinase-Related Protein 1 (TYRP1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Tyrosinase-Related Protein 1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Staining Methods (StM), Coating (Coat)

Clone: TYRP1-3280

Détail du produit anti-Tyrosinase-Related Protein 1 anticorps

Épitope: AA 257-377

Specificité: It reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

Purification: Purified by Protein A/G

Immunogène: A recombinant fragment (around aa 257-377) of human TYRP1 protein (exact sequence is proprietary)

Isotype: IgG2b kappa

Information d'application

Indications d'application:

Positive Control: SK-MEL-23, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells. Human skin or melanoma tissues (IHC).

Known Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Tyrosinase-Related Protein 1

Antigène: Tyrosinase-Related Protein 1 (TYRP1)

Autre désignation: TYRP1

Poids moléculaire: 75kDa

ID gène: 7306

UniProt: P17643