RCAS1 anticorps

N° du produit ABIN6941020

L’anticorps Souris Monoclonal anti-RCAS1 a été validé pour IHC et StM. Il convient pour détecter RCAS1 dans des échantillons de Humain.

Aperçu rapide pour RCAS1 anticorps (ABIN6941020)

Antigène: RCAS1 (EBAG9) (Estrogen Receptor Binding Site Associated, Antigen, 9 (EBAG9))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RCAS1 est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Clone: CPTC-EBAG9-2

Détail du produit anti-RCAS1 anticorps

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length human EBAG9 protein

Isotype: IgG2a kappa

Information d'application

Indications d'application:

Positive Control: MCF-7, Jurkat, 293 cell lysates, Human skeletal muscle tissue.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur RCAS1

Antigène: RCAS1 (EBAG9) (Estrogen Receptor Binding Site Associated, Antigen, 9 (EBAG9))

Autre désignation: EBAG9

Sujet: EBAG9, also known as RCAS1, is an estrogen-transcribed protein. Soluble and membranous RCAS1 proteins may play a role in the immune escape of tumor cells by promoting T lymphocyte inhibition of growth and apoptosis. RCAS1 is expressed in a wide variety of cancers, including uterine, ovarian, and lung cancer cells, and acts as a ligand for a putative receptor present on peripheral lymphocytes. RCAS1 is highly expressed not only in cancer cells but also in non-tumor bile duct cells subject to immune attack. RCAS1 inhibits the in vitro growth of receptor-expressing cells and induces apoptosis, contributing to the ability of tumor cells to evade host immune surveillance. High expression of RCAS1 significantly correlates with tumor progression and with poor outcome for many cancer patients.

Poids moléculaire: 32kDa

ID gène: 9166

UniProt: O00559