Human Papilloma Virus 16 E2 (HPV-16 E2) anticorps

N° du produit ABIN6941308

Cet anticorps Souris Monoclonal détecte spécifiquement Human Papilloma Virus 16 E2 dans WB. Il présente une réactivité avec des échantillons de Human Papillomavirus 16 (HPV-16).

Aperçu rapide pour Human Papilloma Virus 16 E2 (HPV-16 E2) anticorps (ABIN6941308)

Antigène: Human Papilloma Virus 16 E2 (HPV-16 E2)

Reactivité: Human Papillomavirus 16 (HPV-16)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Western Blotting (WB)

Clone: TVG 261

Détail du produit

Purification: Purified by Protein A/G

Immunogène: Raised against Vaccinia-E2 followed by intravenous injection of the maltose binding protein MBP-E2

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: HPV-16 infected cells. Cervical tissue.

Known Application: Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détail du antigène

Antigène: Human Papilloma Virus 16 E2 (HPV-16 E2)

Autre désignation: HPV16 E2 (Human Papilloma Virus 16)

Classe de substances: Viral Protein

Sujet: The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a strain that is responsible for the largest number of cases of cervical cancers linked to the family. HPV16E1 and HPV16E2 are proteins that are involved in the regulation of viral DNA replication and are important for infected cell homeostasis. HPV16E2 specifically regulates the expression of the E6 and E7 oncoproteins by binding to four sites within the viral long control region, possibly involving interactions with nuclear hormone receptors. Integration of the HPV genome into the host DNA usually disrupts the HPV16E2 gene open reading frames, resulting in an overexpression of E6 and E7 genes, an event that may lead to the malignant transformation of cervical cancer. HPV16E2 is also able to induce apoptotic cell death via two pathways: the first through the binding of p53 and the second through the binding of the viral genome.

Poids moléculaire: 43kDa