Aryl Hydrocarbon Receptor anticorps

N° du produit ABIN6942132

Cet anticorps Lapin Monoclonal détecte spécifiquement Aryl Hydrocarbon Receptor dans WB, IHC (p) et IF (cc). Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour Aryl Hydrocarbon Receptor anticorps (ABIN6942132)

Antigène: Aryl Hydrocarbon Receptor (AHR)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Aryl Hydrocarbon Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 3C7

Détail du produit anti-Aryl Hydrocarbon Receptor anticorps

Réactivité croisée: Humain, Souris

Purification: Purified by Protein A.

Immunogène: Human Aryl hydrocarbon Receptor aa 600-800

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur Aryl Hydrocarbon Receptor

Antigène: Aryl Hydrocarbon Receptor (AHR)

Autre désignation: Aryl hydrocarbon Receptor

Sujet:

Synonyms: Class E basic helix-loop-helix protein 76, Ah receptor, AhR, bHLHe76

Background: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates (PubMed:10395741, PubMed:28602820, PubMed:7961644, PubMed:23275542, PubMed:30373764). Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644). Involved in cell-cycle regulation (PubMed:12213388). Likely to play an important role in the development and maturation of many tissues (PubMed:12213388). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).

ID gène: 196

UniProt: P35869

Pathways: Regulation of Cell Size