BAZ1B anticorps

N° du produit ABIN6942236

Cet anticorps anti-BAZ1B est un anticorps Lapin Monoclonal détectant BAZ1B dans WB et FACS. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour BAZ1B anticorps (ABIN6942236)

Antigène: BAZ1B (Bromodomain Adjacent To Zinc Finger Domain, 1B (BAZ1B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp BAZ1B est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 5G1

Détail du produit anti-BAZ1B anticorps

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant protein within C-terminal human BAZ1B.

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 12 months

Détails sur BAZ1B

Antigène: BAZ1B (Bromodomain Adjacent To Zinc Finger Domain, 1B (BAZ1B))

Autre désignation: BAZ1B

Sujet:

Synonyms: Tyrosine-protein kinase BAZ1B, Bromodomain adjacent to zinc finger domain protein 1B, Williams syndrome transcription factor, Williams-Beuren syndrome chromosomal region 10 protein, Williams-Beuren syndrome chromosomal region 9 protein, hWALp2, BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF

Background: Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.

ID gène: 9031

UniProt: Q9UIG0

Pathways: Nuclear Hormone Receptor Binding, Chromatin Binding