CD46 anticorps

N° du produit ABIN6942441

Cet anticorps Lapin Monoclonal détecte spécifiquement CD46 dans WB, IHC (p), IF (cc) et IF (p). Il présente une réactivité envers Humain et Rat.

Aperçu rapide pour CD46 anticorps (ABIN6942441)

Antigène: CD46

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CD46 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Clone: 4C3

Détail du produit anti-CD46 anticorps

Réactivité croisée: Humain, Rat

Purification: Purified by Protein A.

Immunogène: Synthetic peptide within human CD46 aa 50-100

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur CD46

Antigène: CD46

Autre désignation: CD46

Sujet:

Synonyms: Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD46, MCP, MIC10, AHUS2,

Background: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

ID gène: 4179

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization