CXCR3 anticorps

N° du produit ABIN6942741

Détail du produit anti-CXCR3 anticorps

Antigène: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CXCR3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: Human CXCR3 aa 250-350

Clone: 5F2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur CXCR3

Antigène: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Autre désignation: CXCR3 (CXCR3 Produits)

Synonymes: anticorps CD182, anticorps CD183, anticorps CKR-L2, anticorps CMKAR3, anticorps GPR9, anticorps IP10-R, anticorps Mig-R, anticorps MigR, anticorps Cd183, anticorps Cmkar3, anticorps CXCR3, anticorps cxcr3, anticorps Gpr9, anticorps CXC-R3, anticorps CXCR-3, anticorps zgc:92301, anticorps sb:eu378, anticorps C-X-C motif chemokine receptor 3, anticorps chemokine (C-X-C motif) receptor 3, anticorps chemokine (C-X-C motif) receptor 3, tandem duplicate 2, anticorps chemokine (C-X-C motif) receptor 3, tandem duplicate 1, anticorps CXCR3, anticorps Cxcr3, anticorps cxcr3, anticorps cxcr3.2, anticorps cxcr3.1

Sujet:

Synonyms: C-X-C chemokine receptor type 3, CKR-L2, G protein-coupled receptor 9, Interferon-inducible protein 10 receptor, CXC-R3, CXCR-3, IP-10 receptor, IP-10 receptor, CD183, CXCR3, GPR9

Background: Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway. Does not promote cell chemotaxis response. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11.

ID gène: 2833

UniProt: P49682