DNMT3A anticorps

N° du produit ABIN6943093

L’anticorps anti-DNMT3A Polyclonal Lapin est utilisé pour la détection de DNMT3A dans des échantillons de Humain. Il a été validé pour WB, ELISA, IP et ChIP-seq.

Aperçu rapide pour DNMT3A anticorps (ABIN6943093)

Antigène: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNMT3A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), ChIP DNA-Sequencing (ChIP-seq)

Détail du produit anti-DNMT3A anticorps

Réactivité croisée: Humain

Purification: Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.

Immunogène: Polyclonal antibody raised in rabbit against human DNMT3A, (DNA methyltransferase 3A), using a KLH-conjugated synthetic peptide corresponding to amino acids 44-58

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IP(1-2 μg)
ChIP-seq()

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.75 μg/μL

Buffer: PBS with 0.05 % sodium azide and 0.05 % Proclin300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur DNMT3A

Antigène: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Autre désignation: DNMT3A

Sujet:

Synonyms: DNMT3A2, TBRS

Background: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.

ID gène: 1788

UniProt: Q9Y6K1