HNRNPK anticorps

N° du produit ABIN6943705

L’anticorps Lapin Monoclonal anti-HNRNPK a été validé pour WB, IHC, IHC (p) et IF (cc). Il convient pour détecter HNRNPK dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour HNRNPK anticorps (ABIN6943705)

Antigène: HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K (HNRNPK))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp HNRNPK est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 8G5

Détail du produit anti-HNRNPK anticorps

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: N terminus Human HNRNPK

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC()

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur HNRNPK

Antigène: HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K (HNRNPK))

Autre désignation: HNRNPK

Sujet:

Synonyms: Heterogeneous nuclear ribonucleoprotein K, Transformation up-regulated nuclear protein, hnRNP K, TUNP, HNRNPK

Background: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.

ID gène: 3190

UniProt: P61978