MLKL anticorps

N° du produit ABIN6944094

Cet anticorps Lapin Monoclonal détecte spécifiquement MLKL dans WB et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour MLKL anticorps (ABIN6944094)

Antigène: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp MLKL est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 3G4

Détail du produit anti-MLKL anticorps

Réactivité croisée: Humain, Souris

Purification: Purified by Protein A.

Immunogène: Human MLKL between 350 to C-terminus

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC()

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur MLKL

Antigène: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Autre désignation: MLKL

Sujet:

Synonyms: Mixed lineage kinase domain-like protein, hMLKL, MLKL

Background: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610).

ID gène: 197259

UniProt: Q8NB16