MYH11 anticorps (Heavy Chain)

N° du produit ABIN6944194

L’anticorps anti-MYH11 Monoclonal Lapin est utilisé pour la détection de MYH11 dans des échantillons de Humain. Il a été validé pour WB, IHC (p), IF (p) et IHC (fro).

Aperçu rapide pour MYH11 anticorps (Heavy Chain) (ABIN6944194)

Antigène: MYH11 (Myosin Heavy Chain 11, Smooth Muscle (MYH11))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp MYH11 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 1F11

Détail du produit anti-MYH11 anticorps

Épitope: Heavy Chain

Fonction: smooth muscle Myosin heavy chain 11 Recombinant Antibody

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: C terminal human smooth muscle Myosin heavy chain 11

Isotype: IgG

Information d'application

Indications d'application: WB(WB(1:500-2000)), IHC-P(IHC-P(1:100-500)), IHC-F(IHC-F(1:100-500)), IF(IHC-P)(IF(IHC-P)(1:100-500))

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur MYH11

Antigène: MYH11 (Myosin Heavy Chain 11, Smooth Muscle (MYH11))

Autre désignation: MYH11

Sujet:

Synonyms: Myosin-11, Myosin heavy chain 11, Myosin heavy chain, smooth muscle isoform, SMMHC, MYH11, KIAA0866

Background: The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16[inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. MYH11 is a smooth muscle myosin belonging to the myosin heavy chain family. It is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP.

ID gène: 4629

UniProt: P35749