NDEL1 anticorps (N-Term)

N° du produit ABIN6944228

Cet anticorps anti-NDEL1 Monoclonal Lapin (Clone 7A1) (ABIN6944228) détecte spécifiquement NDEL1 dans WB et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour NDEL1 anticorps (N-Term) (ABIN6944228)

Antigène: NDEL1 (NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 (NDEL1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp NDEL1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 7A1

Détail du produit anti-NDEL1 anticorps

Épitope: N-Term

Fonction: NDEL1 (7A1) Monoclonal Antibody

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant protein corresponding to the N-terminus of human Nudel.

Isotype: IgG

Information d'application

Indications d'application: WB(1:300-5000), IHC-P(1:200-400)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur NDEL1

Antigène: NDEL1 (NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 (NDEL1))

Autre désignation: NDEL1

Sujet:

Synonyms: Nuclear distribution protein nudE-like 1, Mitosin-associated protein 1, Protein Nudel, NDEL1, EOPA, MITAP1, NUDEL, nudE neurodevelopment protein 1 like 1, NDE1L1

Background: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.

ID gène: 81565

UniProt: Q9GZM8

Pathways: Regulation of Cell Size