Recombinant Retinoid X Receptor alpha anticorps (N-Term)

N° du produit ABIN6944804

Cet anticorps anti-Retinoid X Receptor alpha Monoclonal Lapin (ABIN6944804) détecte spécifiquement Retinoid X Receptor alpha dans WB, FACS, IF, ICC et IP. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant Retinoid X Receptor alpha anticorps (N-Term) (ABIN6944804)

Antigène: Retinoid X Receptor alpha (RXRA) (Retinoid X Receptor, alpha (RXRA))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Retinoid X Receptor alpha est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Détail du produit anti-Retinoid X Receptor alpha anticorps

Épitope: N-Term

Fonction: Retinoid X Receptor alpha Recombinant Antibody

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant protein corresponding to N-terminal human Retinoid X Receptor alpha.

Isotype: IgG

Information d'application

Indications d'application: WB(1:500-2000), IP(1:20-50), Flow-Cyt(1:50-100), ICC/IF(1:50-200)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur Retinoid X Receptor alpha

Antigène: Retinoid X Receptor alpha (RXRA) (Retinoid X Receptor, alpha (RXRA))

Autre désignation: RXRA

Sujet:

Synonyms: Retinoic acid receptor RXR-alpha, Nuclear receptor subfamily 2 group B member 1, Retinoid X receptor alpha, RXRA, NR2B1

Background: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.

ID gène: 6256

UniProt: P19793

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Hepatitis C