SAMHD1 anticorps
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- Antigène Voir toutes SAMHD1 Anticorps
- SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp SAMHD1 est non-conjugé
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Réactivité croisée
- Humain
- Purification
- Purified by Protein A.
- Immunogène
- Synthetic peptide within human SAMHD1 aa 600 to the C-terminus
- Clone
- 16C6
- Isotype
- IgG
- Top Product
- Discover our top product SAMHD1 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))
- Autre désignation
- SAMHD1 (SAMHD1 Produits)
- Synonymes
- anticorps CHBL2, anticorps DCIP, anticorps HDDC1, anticorps MOP-5, anticorps SBBI88, anticorps si:dkeyp-44b8.8, anticorps E330031J07Rik, anticorps Mg11, anticorps SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1, anticorps SAM domain and HD domain 1, anticorps SAM domain and HD domain, 1, anticorps SAMHD1, anticorps samhd1, anticorps Samhd1
- Sujet
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Synonyms: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, Dendritic cell-derived IFNG-induced protein, Monocyte protein 5, SAM domain and HD domain-containing protein 1, dNTPase, DCIP, MOP-5, SAMHD1, MOP5.
Background: SAMHD1 may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. SAMHD1 is a cellular enzyme, responsible for blocking replication of HIV in dendritic cells, macrophages and monocytes. It is an enzyme that exhibits phosphohydrolase activity, converting deoxynucleoside triphosphates (dNTPs) to inorganic phosphate (iPPP) and a 2'-deoxynucleoside (i.e. deoxynucleosides without a phosphate group). In doing so, SAMHD1 depletes the pool of dNTPs available to a reverse transcriptase for viral cDNA synthesis and thus prevents viral replication. SAMHD1 has also shown nuclease activity. Although a ribonuclease activity was described to be required for HIV-1 restriction, recent data confirmed that SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity.
- ID gène
- 25939
- UniProt
- Q9Y3Z3
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