UBA1 anticorps

N° du produit ABIN6945248

Cet anticorps anti-UBA1 est un anticorps Lapin Monoclonal détectant UBA1 dans WB, IHC, IF (cc), IHC (p) et FACS. Adapté pour Humain, Rat et Souris.

Aperçu rapide pour UBA1 anticorps (ABIN6945248)

Antigène: UBA1 (Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp UBA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: 8A4

Détail du produit anti-UBA1 anticorps

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Human Ubiquitin-like modifier-activating enzyme 1 between 1000 amino acids to C-terminus

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC()

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur UBA1

Antigène: UBA1 (Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1))

Autre désignation: Ubiquitin-like modifier-activating enzyme 1

Sujet:

Synonyms: Ubiquitin-like modifier-activating enzyme 1, Protein A1S9, Ubiquitin-activating enzyme E1, UBA1

Background: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334).

ID gène: 7317

UniProt: P22314