SIRPA anticorps (AA 31-370)

N° du produit ABIN6961045

Détail du produit anti-SIRPA anticorps

Antigène: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Épitope: AA 31-370

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp SIRPA est non-conjugé

Application: Flow Cytometry (FACS), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Purification: Purified from cell culture supernatant by affinity chromatography

Immunogène: Recombinant human SIRPalpha (Glu31-Arg370) (ABIN6961082) produced by using human HEK293 cells

Clone: DM8

Isotype: IgG

Information d'application

Indications d'application: Flow Cyt  1/100, IP 1/30

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 % Glycerol, PBS, pH 7.4, 0.1 % BSA, 0.1 % Procline 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détails sur SIRPA

Antigène: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Autre désignation: SIRPalpha (SIRPA Produits)

Synonymes: anticorps BIT, anticorps CD172A, anticorps MFR, anticorps MYD-1, anticorps P84, anticorps PTPNS1, anticorps SHPS1, anticorps SIRP, anticorps SIRPA, anticorps SIRP-A1, anticorps SIRP-B1, anticorps AI835480, anticorps Bit, anticorps CD172a, anticorps Ptpns1, anticorps SHP-1, anticorps SHPS-1, anticorps swc3, anticorps signal regulatory protein alpha, anticorps myeloperoxidase, anticorps signal-regulatory protein alpha, anticorps tyrosine-protein phosphatase non-receptor type substrate 1, anticorps SIRPA, anticorps MPO, anticorps LOC458039, anticorps LOC100400378, anticorps LOC100590224, anticorps Sirpa

Sujet: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

Poids moléculaire: 55 kDa

ID gène: 140885

UniProt: P78324