PD-1 anticorps
-
- Antigène Voir toutes PD-1 (PDCD1) Anticorps
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
-
Reactivité
- Souris
-
Hôte
-
Hamster arménien
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp PD-1 est non-conjugé
-
Application
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Purification
- This monoclonal antibody preparation was purified from tissue culture supernatant via affinity chromatography. For In Vivo Ready™ (IVR) products, each preparation is also evaluated for endotoxin levels using the LAL assay. It is recommended to store the product undiluted at 4°C. Do not freeze.
- Clone
- J43-1
- Isotype
- IgG
- Top Product
- Discover our top product PDCD1 Anticorps primaire
-
-
- Indications d'application
- This purified format is guaranteed to be >90 % pure as determined by SDS-PAGE analysis.
- Commentaires
-
0.5 mg/mL
- Restrictions
- For Research Use only
-
- Buffer
- 10 mM NaH2PO4, 150 mM NaCl, 0.09 % Sodium azide, pH 7.2
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- 2-8°C
- Date de péremption
- 12 months
-
- Antigène
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
- Autre désignation
- CD279 (PD-1) (PDCD1 Produits)
- Synonymes
- anticorps CD279, anticorps PD-1, anticorps PD1, anticorps SLEB2, anticorps hPD-1, anticorps hPD-l, anticorps Ly101, anticorps Pdc1, anticorps programmed cell death 1, anticorps PDCD1, anticorps Pdcd1
- Sujet
- The J43.1 antibody is specific for mouse CD279, also known as programmed death-1 (PD-1), a 55 kDa glycoprotein which can co- regulate T cell antigen receptor signaling and therefore modulate T cell activation. PD-1 exists in a monomeric form that is expressed by CD4- CD8- thymocytes, where it participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and develop- ment of tolerance. PD-1 expression is also inducible upon activation of mature T cells, where it has been proposed to interact with the co- stimulatory receptor CD80 to limit T cell activation. Two ligands for PD-1, known as PD-L1 (B7-H1) and PD-L2 (B7-DC) are differentially expressed on T and B cells, monocytes, macrophages, NK cells or dendritic cells. PD-1 is a member of a family of receptors including CD28 and CTLA-4 (CD152), which interact with ""B7"" ligands to provide a balance of co-stimulatory /co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.The J43.1 antibody may be used as a marker for PD-1 expression, and is commonly used for analysis of receptor-ligand interaction and function(s) in vitro and in vivo.
- ID gène
- 18566
- Pathways
- Cancer Immune Checkpoints
-