BAZ2A anticorps (N-Term)

N° du produit ABIN6971425

Cet anticorps anti-BAZ2A est un anticorps Lapin Polyclonal détectant BAZ2A dans WB et IF. Adapté pour Humain.

Aperçu rapide pour BAZ2A anticorps (N-Term) (ABIN6971425)

Antigène: BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAZ2A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-BAZ2A anticorps

Épitope: N-Term

Attributs du produit: BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A) is an essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter, pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). BAZ2A antibody (pAb) was raised in a Rabbit host. It has been validated for use in Immunofluorescence and Western blot, it has been shown to react with Human samples.

Purification: Affinity Purified

Immunogène: This antibody was raised against a peptide within the N-terminal region of human BAZ2A.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Détails sur BAZ2A

Antigène: BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))

Autre désignation: BAZ2A

Poids moléculaire: 270 kDa

NCBI Accession: NP_038477