Cxxc4 (CXXC Finger Protein 4) acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 and has been implicated in malignant renal cell carcinoma and colonic villous adenoma. Recently, Cxxc4 has been shown to be involved in the regulation of DNA demethylation. It binds to unmethylated CpGs in DNA and is involved in TET2 downregulation. Cxxc4 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human and Mouse samples.
Purification
Affinity Purified
Immunogène
This antibody was raised against a peptide within the N-terminal region of mouse Cxxc4.
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Buffer
Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Stockage commentaire
Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.