LXR-alpha (N-Term) anticorps

N° du produit ABIN6972296

Cet anticorps Lapin Polyclonal détecte spécifiquement LXR-alpha dans ChIP-seq, ChIP et WB. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour LXR-alpha (N-Term) anticorps (ABIN6972296)

Antigène: LXR-alpha

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Application: ChIP DNA-Sequencing (ChIP-seq), Chromatin Immunoprecipitation (ChIP), Western Blotting (WB)

Détail du produit

Épitope: N-Term

Attributs du produit: LXR-a (Liver X receptor alpha, NR1H3) is an orphan nuclear receptor and a member of the NR1 receptor family. The LXR receptors (including LXR-a and LXR-b) bind oxysterols and play key roles in maintaining cholesterol homeostasis in macrophages, primarily by regulating multiple components of the reverse cholesterol transport. They also are potent inhibitors of inflammation and are capable of repressing cytokine and chemokine production by Toll-like receptor (TLR)-activated macrophages. LXR-a is expressed mainly in liver and adipose tissue and interacts with RXR, shifting RXR to an active ligand-binding subunit mediating responses to retinoids. LXR-alpha antibody (pAb) was raised in a Rabbit host. It has been validated for use in Chromatin Immunoprecipitation, ChIP-Seq and Western blot, it has been shown to react with Human and Mouse samples.

Purification: Affinity Purified

Immunogène: This LXR-α antibody was raised against a peptide in the N-terminal region of human LXR-α.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Purified rabbit IgG in 70 mM Tris, 105 mM EDTA, 31 mM glycine, 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Détail du antigène

Antigène: LXR-alpha

Autre désignation: LXR-α

Poids moléculaire: 52 kDa

NCBI Accession: NP_005684