RING1 anticorps (C-Term)

N° du produit ABIN6972601

Détail du produit anti-RING1 anticorps

Antigène: RING1 (Ring Finger Protein 1 (RING1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RING1 est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: RING1 (Ring Finger Protein 1) constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. RING1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Purification: Affinity Purified

Immunogène: This antibody was raised against a peptide within the C-terminal region of human RING1.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Détails sur RING1

Antigène: RING1 (Ring Finger Protein 1 (RING1))

Autre désignation: RING1 (RING1 Produits)

Synonymes: anticorps RING1A, anticorps RNF1, anticorps Ring1A, anticorps bap-1, anticorps bap1, anticorps ding, anticorps hipi3, anticorps ring1a, anticorps ring1b, anticorps ring2, anticorps rnf1, anticorps rnf2-a, anticorps ring1, anticorps ring1b-B, anticorps rnf2-b, anticorps ring finger protein 1, anticorps ring finger protein 1 S homeolog, anticorps ring finger protein 1 L homeolog, anticorps RING1, anticorps Ring1, anticorps ring1.S, anticorps ring1.L

Poids moléculaire: 50 kDa

NCBI Accession: NP_002922