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SATB1 anticorps (N-Term)

SATB1 Reactivité: Humain, Souris WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6972695
  • Antigène Voir toutes SATB1 Anticorps
    SATB1 (SATB Homeobox 1 (SATB1))
    Épitope
    • 16
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 60
    • 47
    • 29
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    Humain, Souris
    Hôte
    • 54
    • 5
    • 1
    Lapin
    Clonalité
    • 47
    • 13
    Polyclonal
    Conjugué
    • 30
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SATB1 est non-conjugé
    Application
    • 27
    • 21
    • 14
    • 14
    • 12
    • 11
    • 10
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Attributs du produit
    SATB1 (Special AT-rich sequence-binding protein 1) is a chromosome-associated protein that binds to matrix attachment regions (MARs) of DNA at special AT-rich sequences and induces local chromatin-loop remodeling. SATB1 functions as both a chromatin organizer and transcription factor. It regulates gene expression and higher-order chromatin structure of multigene clusters. SATB1 acts as a docking site for several chromatin remodeling enzymes and recruits corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. It is required for the switching of fetal globin genes, plays a role in chromatin organization and nuclear architecture during apoptosis. It is a crucial factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis. SATB1 contributes to metastatic potential in breast cancer cells, directly upregulating metastasis-associated genes while downregulating tumor-suppressor genes. It is also required for the differentiation of embryonic stem cells through repression of ES pluripotency factors Nanog, Klf4, and Tbx3. SATB1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human and Mouse samples.
    Purification
    Affinity Purified
    Immunogène
    This SATB1 antibody was raised against a peptide within the N-terminal region of SATB1.
    Isotype
    IgG
    Top Product
    Discover our top product SATB1 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Antigène
    SATB1 (SATB Homeobox 1 (SATB1))
    Autre désignation
    SATB1 (SATB1 Produits)
    Synonymes
    anticorps 2610306G12Rik, anticorps AW413156, anticorps SATB1, anticorps sb:cb955, anticorps si:ch211-195k18.2, anticorps SATB homeobox 1, anticorps special AT-rich sequence binding protein 1, anticorps SATB homeobox 1a, anticorps SATB1, anticorps Satb1, anticorps satb1, anticorps satb1a
    Poids moléculaire
    105 kDa
    NCBI Accession
    NP_001124482
    Pathways
    Caspase Cascade in Apoptosis, Activated T Cell Proliferation
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