Ubinuclein 1 anticorps (AA 1-345)

N° du produit ABIN6972900

Détail du produit anti-Ubinuclein 1 anticorps

Antigène: Ubinuclein 1 (UBN1)

Épitope: AA 1-345

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ubinuclein 1 est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: UBN1 (Ubinuclein 1, also known as HIRA binding protein) is a ubiquitously expressed nuclear protein that acts as a novel regulator of senescence. UBN1 is involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. It is expressed in a number of cancer cell lines and tumors and may be required for replication-independent chromatin assembly. UBN1 is part of a large multi-subunit protein complex that interacts with CEBPA and Epstein-Barr virus BLZF1. It co-localizes with HIRA, PML and SP100 in the PML bodies of senescent cells. When overexpressed, UBN1 accumulates in the nucleus of cells defective for cytokinesis. Ubn1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Purification: Affinity Purified

Immunogène: This Ubinuclein antibody was raised against a recombinant protein corresponding to amino acids 1-345 of human Ubn1.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Détails sur Ubinuclein 1

Antigène: Ubinuclein 1 (UBN1)

Autre désignation: Ubn1 (UBN1 Produits)

Synonymes: anticorps ubinuclein-1, anticorps ubn1, anticorps VT, anticorps VT4, anticorps 1110029L11Rik, anticorps 2610108L02Rik, anticorps AA673476, anticorps AW124741, anticorps ubinuclein 1, anticorps UBN1, anticorps ubn1, anticorps Ubn1

Poids moléculaire: 145 kDa

NCBI Accession: NP_001072982