LRP1 anticorps (AA 2501-2600) (Biotin)

N° du produit ABIN6982580

L’anticorps Lapin Polyclonal anti-LRP1 a été validé pour WB, ELISA et IHC (p). Il convient pour détecter LRP1 dans des échantillons de Humain.

Aperçu rapide pour LRP1 anticorps (AA 2501-2600) (Biotin) (ABIN6982580)

Antigène: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRP1 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-LRP1 anticorps (Biotin)

Épitope: AA 2501-2600

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human LRP1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur LRP1

Antigène: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Autre désignation: LRP1

Sujet:

Synonyms: A2MR, Alpha 2 macroglobulin receptor, alpha 2MR, APOER, Apolipoprotein E receptor, APR, CD 91, CD91, CD91 antigen, Low density lipoprotein receptor related protein 1, Low density lipoprotein related protein 1, LRP 1, LRP 515, LRP 85, LRP, LRP ICD, LRP1, LRP1 protein, LRP515.

Background: Low density lipoprotein receptor-related protein (also known as low density LRP, LRP1, alpha-2-macroglobulin receptor or Apolipoprotein E receptor) is an endocytotic receptor that is involved both in endocytosis and in phagocytosis of apoptotic cells. It is required for early embryonic development, is involved in cellular lipid homeostasis, and may play a role in APP metabolism, kinase-dependent intracellular signalling, neuronal calcium signalling and neurotransmission. Low density LRP also plays a role in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha-2-macroglobulin), and is involved in the local metabolism of complexes of plasminogen activators and their endogenous ligands. Low density LPR is postulated to be one of the major players in host resistance to HIV. The precursor low density LRP molecule is cleaved post-translationally to form a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515), which remains non-covalently associated with LRP-85. Following cleavage, the intracellular domain (LPRICD) is present in both the cytoplasm and the nucleus.

ID gène: 4035

UniProt: Q07954

Pathways: Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling