HMGN2 anticorps (Biotin)

N° du produit ABIN6982662

Cet anticorps anti-HMGN2 est un anticorps Lapin Polyclonal détectant HMGN2 dans IHC (p). Adapté pour Rat et Souris.

Aperçu rapide pour HMGN2 anticorps (Biotin) (ABIN6982662)

Antigène: HMGN2 (High Mobility Group Nucleosomal Binding Domain 2 (HMGN2))

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HMGN2 est conjugé à/à la Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-HMGN2 anticorps (Biotin)

Réactivité croisée: Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HMGN2/HMG17:2-60/90

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur HMGN2

Antigène: HMGN2 (High Mobility Group Nucleosomal Binding Domain 2 (HMGN2))

Autre désignation: HMGN2/HMG17

Sujet:

Synonyms: High mobility group (nonhistone chromosomal) protein 17, high mobility group nucleosomal binding domain 2, High mobility group nucleosome-binding domain-containing protein 2, High mobility group protein N2, HMG17, HMGN2, HMGN2_HUMAN, MGC5629, Non histone chromosomal protein HMG 17, Non-histone chromosomal protein HMG-17, Nonhistone chromosomal protein HMG 17, nonhistone chromosomal protein hmg-17.

Background: The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription (15). HMG-14 and HMG-17 also function as architectural elements, which alter the structure of the chromatin fiber and enhance transcription from chromatin templates (13,5). HMG-14/17 proteins modify the nucleosomal organization of the 30 nm chromatin fiber and mediate the unfolding of the higher order chromatin structure thereby facilitating access to the underlying DNA sequence (13). Clustering of architectural elements, such as HMG proteins and linker histone subtypes into distinct domains, may lead to structural and functional heterogeneity along the chromatin fiber (13). In addition, HMG-14 and HMG-17 have been identified as constitutive components of mouse oocyte and embryonic chromatin that establish a link between the structure of embryonic chromatin and the normal progression of embryonic development (2). Post-translational modifications : Phosphorylation favors cytoplasmic localization. Similarity : Belongs to the HMGN family.

ID gène: 3151

UniProt: P05204