HMGN2 anticorps

N° du produit ABIN6989665

Cet anticorps Lapin Monoclonal détecte spécifiquement HMGN2 dans WB, IHC (p) et IF (cc). Il présente une réactivité envers Humain.

Aperçu rapide pour HMGN2 anticorps (ABIN6989665)

Antigène: HMGN2 (High Mobility Group Nucleosomal Binding Domain 2 (HMGN2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp HMGN2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 8H5

Détail du produit anti-HMGN2 anticorps

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: Synthetic Peptide within N terminal human HMGN2.

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur HMGN2

Antigène: HMGN2 (High Mobility Group Nucleosomal Binding Domain 2 (HMGN2))

Autre désignation: HMGN2

Sujet:

Synonyms: High mobility group (nonhistone chromosomal) protein 17 antibody, high mobility group nucleosomal binding domain 2 antibody, High mobility group nucleosome-binding domain-containing protein 2 antibody, High mobility group protein N2 antibody, HMG17 antibody, HMGN2 antibody, HMGN2_HUMAN antibody, MGC5629 antibody, Non histone chromosomal protein HMG 17 antibody, Non-histone chromosomal protein HMG-17 antibody, Nonhistone chromosomal protein HMG 17 antibody, nonhistone chromosomal protein hmg-17 antibody

Background: The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription (15). HMG-14 and HMG-17 also function as architectural elements, which alter the structure of the chromatin fiber and enhance transcription from chromatin templates (13,5). HMG-14/17 proteins modify the nucleosomal organization of the 30 nm chromatin fiber and mediate the unfolding of the higher order chromatin structure thereby facilitating access to the underlying DNA sequence (13). Clustering of architectural elements, such as HMG proteins and linker histone subtypes into distinct domains, may lead to structural and functional heterogeneity along the chromatin fiber (13). In addition, HMG-14 and HMG-17 have been identified as constitutive components of mouse oocyte and embryonic chromatin that establish a link between the structure of embryonic chromatin and the normal progression of embryonic development (2).

ID gène: 3151

UniProt: P05204