UBE2O anticorps

N° du produit ABIN6989899

Cet anticorps Lapin Polyclonal détecte spécifiquement UBE2O dans WB, IF (cc), IP et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour UBE2O anticorps (ABIN6989899)

Antigène: UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBE2O est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunoprecipitation (IP), Immunofluorescence (IF)

Détail du produit anti-UBE2O anticorps

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1073-1292 of human UBE2O (NP_071349.3).

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IF(ICC) 1:50-200
IP(1-2 μg)
IF()

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur UBE2O

Antigène: UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))

Autre désignation: UBE2O

Sujet:

Synonyms: UBE2O,E2-230K

Background: UBE20, also known as E2-230K, is a 1,292 amino acid member of the uniquitin-conjugating enzyme family that is involved in protein modification. Expressed predominately in heart and skeletal muscle, UBE2O functions to catalyze the ATP-dependent covalent attachment of ubiquitin to select proteins, thereby targeting the ubiquitinated proteins for proteasomal degradation. The gene encoding UBE2O maps to human chromosome 17, which comprises over 2.5 % of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

ID gène: 63893

UniProt: Q9C0C9