ACE2 anticorps (AA 150-200)
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- Antigène Voir toutes ACE2 Anticorps
- ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))
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Épitope
- AA 150-200
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ACE2 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
- Specificité
- Anti-ACE2 has no cross response to ACE1.
- Purification
- ACE2 Antibody is affinity chromatography purified via peptide column.
- Immunogène
- ACE2 antibody was raised against a synthetic peptide corresponding to amino acids near the center of human ACE2. The immunogen is located within amino acids 150 - 200 of ACE2.
- Isotype
- IgG
- Top Product
- Discover our top product ACE2 Anticorps primaire
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- Indications d'application
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WB: 4 μ,g/mL, IHC: 2 μ,g/mL, IF: 20 μ,g/mL.
Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in human, mouse and rat samples, Immunofluorescence in human, mouse, and rat samples. All other applications and species not yet tested. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- ACE2 Antibody is supplied in PBS containing 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,4 °C
- Stockage commentaire
- ACE2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Antigène
- ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))
- Autre désignation
- ACE2 (ACE2 Produits)
- Synonymes
- anticorps ACE1, anticorps CD143, anticorps DCP, anticorps DCP1, anticorps ICH, anticorps MVCD3, anticorps ACEH, anticorps 2010305L05Rik, anticorps zgc:92514, anticorps angiotensin I converting enzyme, anticorps angiotensin I converting enzyme 2, anticorps angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, anticorps ACE, anticorps ACE2, anticorps Ace2, anticorps ace2
- Sujet
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ACE2 Antibody: Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. Homology modeling shows 2019-nCoV has a similar receptor-binding domain structure as SARS-CoV, which suggests COVID-19 (2019-nCoV) may use ACE2 as a receptor in humans for infection. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
- Poids moléculaire
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Predicted: 93kD
Observed: 130 kD (7 N-linked glycosylation) kDa - ID gène
- 59272
- NCBI Accession
- NP_068576
- UniProt
- Q9BYF1
- Pathways
- ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour
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