SKIL anticorps (N-Term)

N° du produit ABIN6990331

Cet anticorps Lapin Polyclonal détecte spécifiquement SKIL dans WB, ELISA, IHC (p) et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour SKIL anticorps (N-Term) (ABIN6990331)

Antigène: SKIL (SKI-Like Oncogene (SKIL))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SKIL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-SKIL anticorps

Épitope: N-Term

Purification: SnoN Antibody is affinity chromatography purified via peptide column.

Immunogène: SnoN antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human SnoN. The immunogen is located within the first 50 amino acids of SnoN.

Isotype: IgG

Information d'application

Indications d'application: SnoN antibody can be used for detection of SnoN by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: SnoN Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: SnoN antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SKIL

Antigène: SKIL (SKI-Like Oncogene (SKIL))

Autre désignation: SnoN

Sujet: SnoN Antibody: TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells. There are at least four alternately spliced isoforms of SnoN, SnoN antibody will recognize all isoforms (SnoN, SnoN2, SnoI, and SnoA).

ID gène: 6498

NCBI Accession: NP_005405

UniProt: P12757

Pathways: Positive Regulation of Response to DNA Damage Stimulus