FAIM3 anticorps (C-Term)

N° du produit ABIN6990337

Détail du produit anti-FAIM3 anticorps

Antigène: FAIM3 (Fas Apoptotic Inhibitory Molecule 3 (FAIM3))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAIM3 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Toso Antibody is affinity chromatography purified via peptide column.

Immunogène: Toso antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human Toso. The immunogen is located within the first 50 amino acids of Toso.

Isotype: IgG

Information d'application

Indications d'application: Toso antibody can be used for detection of Toso by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Toso Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Toso antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur FAIM3

Antigène: FAIM3 (Fas Apoptotic Inhibitory Molecule 3 (FAIM3))

Autre désignation: Toso (FAIM3 Produits)

Synonymes: anticorps FAIM3, anticorps FCMR, anticorps TOSO, anticorps 1810037B05Rik, anticorps FcmuR, anticorps Toso, anticorps Fc fragment of IgM receptor, anticorps FCMR, anticorps Fcmr

Sujet: Toso Antibody: Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.

Poids moléculaire: Predicted: 43 kDa

Observed: 41 kDa

ID gène: 9214

NCBI Accession: NP_005440

UniProt: O60667